Pharmacological properties
The drug has analgesic, antipyretic and anti-inflammatory effects. The components of the drug are synergists. The antipyretic effect of acetylsalicylic acid is realized through the central nervous system by inhibiting the synthesis of prostaglandins pgf2 in the hypothalamus in response to the effects of endogenous pyrogens. The analgesic effect has both peripheral and central origin: the peripheral effect is inhibition of the synthesis of prostaglandins in inflamed tissues; the central effect is the effect on the centers of the hypothalamus. Acetylsalicylic acid also reduces platelet aggregation. Paracetamol has an analgesic, antipyretic and very weak anti-inflammatory effect, which is associated with its effect on the thermoregulation center in the hypothalamus and a weak ability to inhibit the synthesis of prostaglandins in peripheral tissues. Caffeine excites the central nervous system. It also enhances positive conditioned reflexes, stimulates motor activity, reduces the effects of sleeping pills and narcotics, and enhances the effects of analgesics and antipyretics.