Validol-Darnitsa

Validol-Darnitsa tablets 60 mg blister 10 pcs Валидол-Дарница таблетки по 60 мг блистер 10 шт
Pharmacological properties Pharmacodynamics. Validol is a complex substance formed by dissolving menthol in the menthyl ester of isovaleric acid. When used sublingually, the effect of the drug is due to the effects of menthol and isovaleric acid ester. The first, by irritating the sensitive nerve endings on the oral mucosa, has a reflex vasodilatory (including coronary dilating) effect. The second, in the central nervous system, stimulates the formation and release of enkephalins, endorphins, dynorphins and peptides that regulate the sensation of pain. As a result of using the drug, regional blood circulation improves, the severity of pain sensations decreases. The drug has a calming effect. Pharmacokinetics. The drug is rapidly absorbed in the oral cavity and reaches C max in the systemic bloodstream within a few minutes . The effect of the drug when administered sublingually develops within 5 minutes. Partially transformed in the liver. Transformation products are excreted from the body through the intestines with bile. The drug is excreted unchanged from the body with urine and exhaled air.

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